Project 1
Project 1 will apply systems approaches to identify Host Regulatory Gene (HRG) networks that determine the balance between asymptomatic MTB infection and TB disease progression. More...
Project 2
Project 2 will apply systems approaches to dissect the complex problem of TB disease progression in vivo, a first for the field. More...
Cores
1. Admin
The Omics for TB Pathogenesis (OTB) consortium will be directed by Drs. Sherman and Aderem, Program Co-PIs, who will have ultimate oversight of the scientific, financial and administrative aspects of the contract. More...
2. Technology
High throughput genomic and proteomic technologies continue to evolve rapidly in terms of sensitivity, coverage, reproducibility, quantitative accuracy and cost-efficiency. Members of the Technology Core have considerable knowledge and experience in selecting, evaluating, and rapidly implementing appropriate novel technologies to achieve the goals of the research projects. More...
3. Modeling
The goal of the Modeling Core is to integrate data from Projects 1 and 2 to generate a multi-scale predictive gene regulatory network (GRN) model that will link quantitative phenotypes in the host to causative mechanisms and their influences in the pathogen, and vice-versa. More...
4. Data
The overarching goal of the Data Management and Resource Dissemination Core is to ensure the seamless integration of existing and newly generated data, workflows, results and analyses, and additional resources for ready availability to other groups, and eventual dissemination to the broader research community. More...